Effect of parathyroidectomy on bone atrophy induced by renal injury with Na-sulfacetylthiazole.

Intraperitonael administration of 0.1 to 0.2gm/kg Na-Sulfacetylthiazole (SAT) twice a week for 4 weeks induced obstructive nephropathy, and bone changes similar to osteoporosis with a decrease in the X-ray density and calcium content of the tail bone and femur, decrease of femoral cortical thickness and an increase in bone resorption cavities in 3 month old rats. Such bone changes, prevented through prior parathyroidectomy, might be due to increased parathyroid hormone activity secondary to SAT-induced renal injury.